Miaa-376 -

MIAA-376

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Oncology

| Area | Potential Impact | |------|-------------------| | | Provides a first‑in‑class extracellular ligand inhibitor , expanding the druggable proteome beyond intracellular enzymes. | | Immunotherapy | May convert “cold” tumors into “hot” ones, boosting the efficacy of existing checkpoint inhibitors. | | Precision Medicine | Serum MIA‑A could become a predictive companion diagnostic , enabling patient‑selection strategies. | | Drug Discovery | Demonstrates the feasibility of HTS + structure‑guided optimization against a protein–protein interface that was previously deemed “undruggable”. | | Academic‑Industry Collaboration | MIAA-376

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Privacy and Security

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Aerospace and Defense Connections

1️⃣ The Backstory – Where Did MIAA‑376 Come From?

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Interpretation:

The dose‑response curve is steep, indicating a narrow therapeutic window that can be widened when combined with immunotherapy. Importantly, no overt toxicity (≤ 10 % body‑weight loss, normal liver enzymes) was observed at the efficacious dose range. | | Immunotherapy | May convert “cold” tumors